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Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - Eleclazine hydrochloride

Eleclazine hydrochloride

CAS No. 1448754-43-5

Eleclazine hydrochloride ( GS-6615 hydrochloride )

Catalog No. M11926 CAS No. 1448754-43-5

A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Eleclazine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3).
  • Description
    A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF); 42 times more potent than Ranolazine in reducing ischemic burden in vivo (EC50=190 nM).Heart Arrhythmia Phase 3 Clinical
  • Synonyms
    GS-6615 hydrochloride
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    1448754-43-5
  • Formula Weight
    451.83
  • Molecular Formula
    C21H17ClF3N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl
  • Chemical Name
    1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zablocki JA, et al. J. Med. Chem., 2016, 59 (19), pp 9005–90172. Fuller H, et al. Heart Rhythm. 2016 Aug;13(8):1679-86.
3. Bacic D, et al. Heart Rhythm. 2017 Mar;14(3):448-454.
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